Single Cell Acute Leukemia Analysis

Numerous chemotherapy and immunotherapy resistance genes have been identified in cancers in general and acute myeloid leukemia in particular. As a preliminary to this study, the investigators hypothesized the co-expression of these genes in the same cell as a major factor in relapse. This hypothesis was supported in vitro by the study of the evolution of these co-expressions after incubation with chemotherapy drugs. The current study aims to verify this hypothesis by studying the expression of these genes in single-cell samples from relapsed acute myeloid leukemia patients.

NCT Number	NCT06906978
Lead Sponsor	Assistance Publique Hopitaux De Marseille
Conditions	Acute Myeloid Leucemia
Enrollment	40 participants
Start Date	2025-07-31
Primary Completion	2028-07-31 (estimated)
Study Completion	2029-07-31 (estimated)
Updated on ClinicalTrials.gov	2025-04-10