Clinical Trial

Efficacy of Two Ultrasound-guided Intra-articular Injections of Botox® Combined With Custom-made Rigid Splinting in Painful Base-of-thumb Osteoarthritis.

Study acronym: RHIBOTII
Recruiting Phase 2/3
View on ClinicalTrials.gov →
Summary
The main objective of this study will be to compare the effects of 2 intra-articular injections of onabotulinumtoxinA with those of 1 intra-articular injection of onabotulinumtoxinA and 1 of normal saline and those of 2 intra-articular injections of normal saline on base-of-thumb pain at 6 months after the first injection.
Protocol Amendment History 2 amendments
This ClinicalTrials.gov record has been amended 2 times since 2025-03-28; most recent amendment 2026-03-30.
Status change: Not Yet Recruiting → Recruiting 2026-03-30
Trial Details
NCT Number NCT06902805
Lead Sponsor Assistance Publique - Hôpitaux de Paris
Collaborators: URC-CIC Paris Descartes Necker Cochin
Conditions Base-of-thumb Osteoarthritis, Osteoarthritis
Enrollment 120 participants
Start Date 2025-12-03
Primary Completion 2027-05 (estimated)
Study Completion 2028-11 (estimated)
Updated on ClinicalTrials.gov 2026-04-03