Clinical Trial

Personalized Ultrasonic Brain Stimulation for Depression (R61)

Recruiting Phase 1/2
View on ClinicalTrials.gov →
Summary
This study will evaluate a new form of non-invasive brain stimulation for individuals with depression. Personalized low-intensity transcranial focused ultrasound stimulation will be delivered using a range of stimulation parameters during psychological and physiological monitoring. Individualized optimal targets will be selected using structural MRI and diffusion tractography. Brain target engagement will be evaluated using functional MRI.
Protocol Amendment History 2 amendments
This ClinicalTrials.gov record has been amended 2 times since 2025-03-24; most recent amendment 2026-04-29.
Trial Details
NCT Number NCT06902298
Lead Sponsor Brian Mickey
Collaborators: National Institute of Mental Health (NIMH)
Conditions Major Depressive Episode, Depression - Major Depressive Disorder, Treatment-Resistant Major Depressive Disorder
Enrollment 30 participants
Start Date 2025-03-10
Primary Completion 2026-05 (estimated)
Study Completion 2026-11 (estimated)
Updated on ClinicalTrials.gov 2026-05-01