Clinical Trial

Methotrexate or Thiotepa Combined With R-CHOP and Orelabrutinib in CNSL Patients

Name: Methotrexate or Thiotepa Combined With R-CHOP and Orelabrutinib in CNSL Patients — clinical trial record (NCT06901999)
Creator: DataLookout
License: https://creativecommons.org/licenses/by/4.0/

Not Yet Recruiting Phase 2

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Summary

This study is designed as an open-label, prospective, single-arm, single-center trial aimed at evaluating the efficacy and safety of MTX or Thiotepa combined with Orelabrutinib and standard chemotherapy regimens in the treatment of DLBCL patients with central nervous system involvement.

Trial Details

NCT Number	NCT06901999
Lead Sponsor	Ruijin Hospital
Conditions	CNS Lymphoma
Enrollment	23 participants
Start Date	2025-04
Primary Completion	2026-11 (estimated)
Study Completion	2028-11 (estimated)
Updated on ClinicalTrials.gov	2025-03-30