Clinical Trial

Home-Based Transcranial Direct Current Stimulation (tDCS) for Depression in Multiple Sclerosis (MS)

Recruiting Phase 2
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Summary
This project is a double-blind, sham-controlled, parallel-arm, randomized controlled trial. We will recruit n=170 people living with MS, who are experiencing an episode of depression in the context of a major depressive episode (MDE). Using our remotely supervised (RS) tDCS protocol, enrolled participants will complete 30 days of 30-minute tDCS (2.0, DLPFC left anodal) while listening to mindfulness meditation. Over the course of the study, participants will complete assessments of depression and MS symptoms. Participants will be randomized 1:1 active:sham tDCS.
Protocol Amendment History 4 amendments
This ClinicalTrials.gov record has been amended 4 times since 2025-03-24; most recent amendment 2026-06-25.
Status change: Not Yet Recruiting → Recruiting 2025-07-21
Trial Details
NCT Number NCT06901687
Lead Sponsor NYU Langone Health
Collaborators: National Multiple Sclerosis Society
Conditions Multiple Sclerosis, Depression
Enrollment 170 participants
Start Date 2025-08-11
Primary Completion 2028-01-01 (estimated)
Study Completion 2028-06-01 (estimated)
Updated on ClinicalTrials.gov 2026-06-29