Clinical Trial

Effect of L-carnitine Supplementation on Phenylalanine and Brain-derived Neurotrophic Factor Levels in Infants and Children With Phenylketonuria

Active, Not Recruiting Phase 4
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Record status
This record was last updated April 4, 2025 (before its estimated March 1, 2026 completion). Its status may not reflect the trial's current state.
Summary
Effect of L-carnitine supplementation on phenylalanine and brain-derived neurotrophic factor levels in infants and children with phenylketonuria L-carnitine is mainly obtained from foods such as red meat and milk that are limited for PKU patients due to dietary protein restriction. So, L-carnitine deficiency has been described in phenylketonuric patients The aim of this study is to : 1. Compare level of Brain-derived neurotrophic factor in infants and children with phenylketonuria and healthy infants and children. 2. Compare level of phenylalanine and Brain-derived neurotrophic factor before and after L-carnitine supplementation in phenylketonuric patients. 3. Assess Intelligence quotient test before and after L-carnitine supplementation in phenylketonuric patients
Protocol Amendment History 1 amendment
This ClinicalTrials.gov record has been amended once since 2025-03-24.
Trial Details
NCT Number NCT06901323
Lead Sponsor Mansoura University
Conditions Phenylketonuria
Enrollment 176 participants
Start Date 2025-02-01
Primary Completion 2026-03-01 (estimated)
Study Completion 2026-08-01 (estimated)
Updated on ClinicalTrials.gov 2025-04-04