TAVR: The Impact of Prothesis Positioning on Valvular and Coronary Hemodynamics

The aim of this clinical study is to learn more about the effects of TAVR-prosthesis positioning on hemodynamics and the coronary arteries. The main questions it aims to answer are: 1. Does the cardiac magnetic resonance imaging and the echocardiography imaging provide an equivalent alternative to the computer tomography which is the state of the art in evaluating commissural alignment? 2. What effect does the position of the valve on the annular level have, especially its symmetrical and commissural position, on valvular and aortic blood flow characteristics? 3. What is the influence of symmetrical position and the presence of a commissural alignment on the coronary flow after transcatheter aortic valve replacement?

NCT Number	NCT06896227
Lead Sponsor	Heinrich-Heine University, Duesseldorf
Conditions	Transcatheter Aortic Valve Replacement, Transcatheter Aortic Valve Implantation, Commissural Alignment, Commissural Misalignment, Symmetry, Prothesis Positioning, Prosthesis Durability, Aortic Valve Stenosis +1 more
Enrollment	100 participants
Start Date	2024-10-22
Primary Completion	2025-09-01 (estimated)
Study Completion	2025-12-31 (estimated)
Updated on ClinicalTrials.gov	2025-03-26