Clinical Trial

Differential Impact of Pringle and Portal Vein Occlusion on Myocardial Injury After Non-Cardiac Surgeries.

Completed
View on ClinicalTrials.gov →
Summary
This study aims to investigate the impact of hepatic ischemia-reperfusion injury (HIRI) on the incidence of myocardial injury after non-cardiac surgery (MINS) and explore the potential underlying mechanisms. A bidirectional cohort study will be conducted, enrolling patients scheduled for major hepato-biliary surgery. Clinical data, perioperative parameters, and postoperative follow-up data will be systematically collected. The incidence of MINS between patients undergoing Pringle occlusion and portal vein occlusion will be compared, and a multivariate analysis will be performed to identify independent risk factors for MINS, providing a basis for early recognition and prevention of MINS.
Protocol Amendment History 3 amendments
This ClinicalTrials.gov record has been amended 3 times since 2025-03-25; most recent amendment 2026-06-11.
Status change: Recruiting → Completed 2026-06-11
Trial Details
NCT Number NCT06895798
Lead Sponsor Beijing Tsinghua Chang Gung Hospital
Conditions Myocardial Injury After Non-Cardiac Surgery, Ischemia Reperfusion Injury
Enrollment 1,286 participants
Start Date 2025-03-07
Primary Completion 2025-06-15 (estimated)
Study Completion 2026-01-15 (estimated)
Updated on ClinicalTrials.gov 2026-06-12