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Oral Tranexamic Acid After Total Knee Arthroplasty

StatusNot Yet Recruiting
PhasePhase 4
Started
View on ClinicalTrials.gov ↗

Record History

  1. Start date: Jun 1, 2026 to Sep 1, 2026v7
  2. Primary completion date: Jun 1, 2026 to Dec 1, 2026
    • Start date: Jan 1, 2026 to Jun 1, 2026
    • Study completion date: Sep 1, 2026 to May 1, 2027
    v6
  3. Start date: Sep 1, 2025 to Jan 1, 2026
    • Primary completion date: Mar 1, 2026 to Jun 1, 2026
    • Study completion date: Jun 1, 2026 to Sep 1, 2026
    v5
  4. Start date: Jul 1, 2025 to Sep 1, 2025v4
  5. Start date: May 15, 2025 to Jul 1, 2025v3
  6. Interventions: Control group placebo (Drug), Oral-Long Arm (Drug), Oral-Short Arm (Drug) to Control group placebo (Drug), tranexamic acid Oral-Long Arm (Drug), tranexamic acid Oral-Short Arm (Drug)v2
  7. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
This is a prospective, double-blind, randomized controlled trial evaluating the efficacy of oral tranexamic acid (TXA) in total knee arthroplasty (TKA). The study will assess pain, function, and range of motion (ROM) over a 2-year period, with key evaluations at 6 weeks and 90 days postoperatively. Hypothesis: Patients receiving 1.95g oral TXA for 3 or 7 days post-op will show improved pain, function, and ROM at 6 weeks and 90 days, with similar blood loss and transfusion rates as the control group.
Trial Details
NCT Number NCT06894719
Lead Sponsor Rush University Medical Center
Conditions
(from sponsor)		 Total Knee Arthroplasty
Related terms Postoperative Pain
Enrollment 351 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov