Effect of Tirzepatide on Brown Adipose Tissue in Obesity

This study is testing whether a new anti-obesity medicine called tirzepatide can increase the activity of special fat cells in the body that help burn energy. These fat cells are known as brown and beige fat. The study includes women with obesity and will last 24 weeks. Participants will receive either tirzepatide or a placebo (a look-alike injection with no active drug). Researchers will measure the amount and activity of brown fat using medical imaging (PET/CT, MRI, and thermal camera), and examine fat tissue samples to look for changes in gene activity and structure that show beige fat activation. The study will also evaluate how these fat changes affect body weight, energy use, hormone levels, blood sugar, and other health markers. The goal is to learn whether tirzepatide helps improve metabolism by increasing energy-burning fat in addition to reducing appetite.

NCT Number	NCT06893211
Lead Sponsor	University Medical Centre Ljubljana
Conditions	Obesity
Enrollment	34 participants
Start Date	2025-03-18
Primary Completion	2025-11-29 (estimated)
Study Completion	2025-12-20 (estimated)
Updated on ClinicalTrials.gov	2026-07-07