Rehabilitation Paired with VNS for Motor Function Recovery

The goal of this clinical trial is to investigate the efficacy and safety of vagus nerve stimulation (VNS) combined with rehabilitation in improving upper extremity motor function after spontaneous intracerebral hemorrhage (ICH). Researchers will evaluate the efficacy and safety of VNS by comparing the improvements of arm motor function post-ICH in the active VNS combined rehabilitation group with that in the sham VNS combined rehabilitation group (actual intensity 0 mA). Participants in this study will undergo a surgical procedure to implant the VNS system and will subsequently recieve a 6 weeks in-clinic therapy, followed by an additional 6 weeks home exercise. During the final 6 weeks, participants will either recieve in-clinic therapy or maintain their home exercise, depending on their assigned group.

NCT Number	NCT06892574
Lead Sponsor	First Affiliated Hospital of Fujian Medical University Collaborators: Beijing Pins Medical Co., Ltd
Conditions	Spontaneous Intracerebral Hemorrhage, Motor Function, Upper Extremity Injury, Rehabilitation, Vagus Nerve Stimulation
Enrollment	10 participants
Start Date	2025-04-01
Primary Completion	2027-03-31 (estimated)
Study Completion	2027-12-30 (estimated)
Updated on ClinicalTrials.gov	2025-03-26