Optimization of Chrononutrition to Reduce the Risk of Disease in Shift Workers

In this randomized controlled trial, the investigators will assess the health impacts of optimizing the timing of dietary consumption in nurses and nursing assistants who work night shifts, have a habitual eating window of 14 hours or more, and elevated weight. Participants will be randomized to one of three groups: (1) dietary monitoring, (2) dietary monitoring plus 10-hour daytime time-restricted eating (TRE), or (3) TRE with a low-glycemic snack during night shifts. The study includes a 2-week screening/baseline health assessment, with follow-up health assessments at 3-, 6- (primary outcome), and 12 months.

NCT Number	NCT06891352
Lead Sponsor	Salk Institute for Biological Studies Collaborators: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), University of San Diego
Conditions	Night Shift Work, Time Restricted Eating, Overweight, Obesity
Enrollment	180 participants
Start Date	2025-06-02
Primary Completion	2028-08-31 (estimated)
Study Completion	2029-03-03 (estimated)
Updated on ClinicalTrials.gov	2025-12-17