A Clinical Trial to Evaluate the Safety and Efficacy of COM701 in Relapsed Platinum Sensitive Ovarian Cancer

Study acronym: MAIA-ovarian
StatusActive, Not Recruiting
PhasePhase 1/2
Started

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Record History

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  1. Minor Enrollment closed, study ongoing
    • Study sites: 28 to 27
  2. Minor Eligibility criteria expanded, about 20 words
    • Site details revised at 25 of 28 sites
  3. Minor Site contacts updated at 1 of 28 sitesv15
  4. Minor Study sites: 26 to 28v14
  5. Minor Study sites: 25 to 26v13
Show 11 earlier versionsHide 11 earlier versions
  1. Minor Study sites: 22 to 25v12
  2. Minor Study sites: 20 to 22v11
  3. Minor Study sites: 21 to 20v10
  4. Minor Study sites: 11 to 21v9
  5. Minor Study sites: 6 to 11v8
  6. Minor Study sites: 7 to 6v7
  7. Minor Study sites: 5 to 7v6
  8. Minor Study sites: 4 to 5
    • Start date changed from estimate of Jul 22, 2025 to Jul 21, 2025
    v5
  9. Re-verified, no change to tracked fieldsv4
  10. Notable Start date: Apr 2025 to Jul 22, 2025
    • Study sites: 1 to 4
    v3
  11. Notable Trial status: Not Yet Recruiting to Recruiting
    • Start date: Mar 2025 to Apr 2025
    v2
  1. Study First Submitted
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
The goal of this clinical trial is to learn if the experimental antibody COM701 delays the progression of ovarian cancer in participants with Relapsed Platinum Sensitive Ovarian Cancer. It will also learn about the safety of COM701. The main questions the trial aims to answer are: * Does COM701, when used as a maintenance treatment, stop or slow the progression of ovarian cancer? * Does COM701 delay the time to needing a new anti-cancer treatment? * What side effects do participants have when taking COM701? Participants will: * Visit the clinic once every 3 weeks during which the study treatment will be administered intravenously * Undergo various tests and procedures to monitor general health throughout the trial including physical examinations, vital sign measurements (heart rate, blood pressure, breathing, and body temperature), weight measurements, electrocardiography (ECG), blood and urine tests and pregnancy tests if relevant. * Undergo various tests and procedures to assess disease response throughout the trial including tumor imaging by CT scans or MRI to assess the tumor, its location, and size, and the testing of a sample of tumor tissue (from a prior biopsy or a fresh biopsy if feasible, to evaluate tumor response to treatment and to measure levels of tumor markers,
Trial Details
NCT Number NCT06888921
Lead Sponsor Compugen Ltd
Conditions
(from sponsor)
Ovarian Cancer, Ovarian Cancer Recurrent
Related terms Ovarian Neoplasms
Enrollment 60 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov