Single vs Hypofractionated Irradiation For Timely Access to Partial Breast Radiotherapy

Partial Breast Irradiation (PBI) is a targeted radiation approach commonly administered post-lumpectomy, specifically targeting the tumour bed. This targeted therapy reduces the exposure to other nearby tissues such as lungs, heart, and chest wall. However, traditional PBI treatment involves lengthy multiple fraction courses which presents a burden to patients from rural and remote communities, who must travel long distances to receive high quality cancer care. The purpose of this study is to compare single fraction (SF) PBI vs. multiple fraction (MF) PBI.

NCT Number	NCT06885671
Lead Sponsor	British Columbia Cancer Agency
Conditions	Breast Cancer Early Stage Breast Cancer (Stage 1-3)
Enrollment	60 participants
Start Date	2026-06-08
Primary Completion	2029-12-31 (estimated)
Study Completion	2029-12-31 (estimated)
Updated on ClinicalTrials.gov	2026-06-23