Optimizing Patient-centred Outcomes Using Opioid Minimization Strategies: The OPUS Anesthesia Pilot Trial

Up to 40% of patients experience suboptimal recovery in the days following major surgery, limiting their return to functional independence. Few preventive interventions exist, but intravenous dexmedetomidine and lidocaine administered during general anesthesia represent simple strategies that may significantly impact recovery and other patient-centred outcomes after surgery. The goal of this pilot trial is to determine the feasibility of conducting a phase 3 pragmatic adaptive multicentre trial to evaluate the impact of dexmedetomidine and lidocaine administered during major non-cardiac surgery on patient-centred outcomes.

NCT Number	NCT06884540
Lead Sponsor	CHU de Quebec-Universite Laval Collaborators: Canadian Perioperative Anesthesia Clinical Trials (PACT) Group, Canadian Institutes of Health Research (CIHR), International Anesthesia Research Society (IARS)
Conditions	Anesthesia, Anesthesia Complication, Surgery, Quality of Life, Pain, Postoperative, Anesthesia Morbidity, Feasibility Studies, Patient-centredness
Enrollment	100 participants
Start Date	2025-07-15
Primary Completion	2027-04 (estimated)
Study Completion	2027-10 (estimated)
Updated on ClinicalTrials.gov	2026-07-01