Capturing Autobiographical Memory Formation in Real World Spaces Using Multimodal Recordings

The goal of this observational study is to develop novel methods for integrating multimodal data streams with invasive neural recordings to study autobiographical memory (AM) formation in individuals with implanted neurostimulation devices (e.g., NeuroPace RNS) for epilepsy treatment. The main questions it aims to answer are: How does the brain encode and retrieve real-world autobiographical memories? Can multimodal data integration enhance our understanding of memory-related cognitive and neural mechanisms? Participants will: * Use a smartphone-based recording application (CAPTURE app) to collect real-world data. * Have their wearable sensor data (e.g., audio-visual, accelerometry, GPS, autonomic physiology, eye tracking) synchronized with invasive neural recordings. Researchers will analyze these multimodal data streams to develop new analytic approaches for studying memory formation in naturalistic settings, with the long-term goal of informing neuromodulation-based memory enhancement treatments for individuals with memory disorders.

NCT Number	NCT06883981
Lead Sponsor	University of Utah Collaborators: National Institutes of Health (NIH), National Institute of Mental Health (NIMH), University of California, San Diego, University of California, Los Angeles
Conditions	Epilepsy, Autobiographical Memory
Enrollment	50 participants
Start Date	2025-01-30
Primary Completion	2027-03 (estimated)
Study Completion	2028-03 (estimated)
Updated on ClinicalTrials.gov	2025-04-08