Three miRNA Signatures in Glioma: From Molecular Mechanisms to Potential Clinical Application

Individual overexpression of the three miRNAs negatively affects cell viability and proliferation mainly in grade III IDH-wild type cells, while in higher grade cells, the effect is more pronounced when the entire signature is overexpressed, individual and combined overexpression of the signature members is able to determine a significant reduction in both migration and invasion. Therefore, ectopic expression of the miRNAs identified by us has a negative impact on cell viability, proliferation and apoptosis, but above all on migration and invasion.

NCT Number	NCT06883214
Lead Sponsor	Regina Elena Cancer Institute Collaborators: University of Roma La Sapienza, San Camillo Hospital, Rome, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Neuromed IRCCS
Conditions	Glioma
Enrollment	10 participants
Start Date	2023-01-17
Primary Completion	2027-01-17 (estimated)
Study Completion	2027-01-17 (estimated)
Updated on ClinicalTrials.gov	2026-06-05