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The Locus Coeruleus, Norepinephrine and Cognitive Aging

StatusActive, Not Recruiting
PhaseNot applicable
Started
View on ClinicalTrials.gov ↗
Record status
This record was last updated May 6, 2026 (before its estimated July 1, 2026 completion). Its status may not reflect the trial's current state.

Record History

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  1. Trial status changed: Recruiting → Active, Not Recruiting
    • Site details revised
    v4
  2. Trial status: Active, Not Recruiting to Recruiting
    • Primary and study completion dates: Jan 1, 2026 to Jul 1, 2026
    • Site details revised
    v3
  3. Primary endpoints: 3 to 5
    • Trial status: Not Yet Recruiting to Active, Not Recruiting
    • Site contact updated
    v2
  4. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
The locus coeruleus (LC) has recently been identified as one of the earliest sites of damage in AD with pathological lesions appearing as early as the mid-20s. In this study, the investigators use a variety of techniques including structural MRI, functional MRI, pupillometry, and transcutaneous vagus nerve stimulation to assess the health of the LC and its relation to easily measurable peripheral variables.
Trial Details
NCT Number NCT06880510
Lead Sponsor Cornell University
Conditions
(from sponsor)		 Alzheimer Disease
Related terms Alzheimer Disease
Enrollment 150 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov