Clinical Trial

The Locus Coeruleus, Norepinephrine and Cognitive Aging

Active, Not Recruiting
View on ClinicalTrials.gov →
Record status
This record was last updated May 6, 2026 (before its estimated July 1, 2026 completion). Its status may not reflect the trial's current state.
Summary
The locus coeruleus (LC) has recently been identified as one of the earliest sites of damage in AD with pathological lesions appearing as early as the mid-20s. In this study, the investigators use a variety of techniques including structural MRI, functional MRI, pupillometry, and transcutaneous vagus nerve stimulation to assess the health of the LC and its relation to easily measurable peripheral variables.
Protocol Amendment History 1 change
critical Trial status changed: Recruiting → Active, Not Recruiting 2026-05-07
Trial Details
NCT Number NCT06880510
Lead Sponsor Cornell University
Conditions Alzheimer Disease
Enrollment 150 participants
Start Date 2025-06-01
Primary Completion 2026-07-01 (estimated)
Study Completion 2026-07-01 (estimated)
Updated on ClinicalTrials.gov 2026-05-06