Mitochondrial Function and Metabolomic Profile in Alzheimer's Disease and Related Dementias

This project aims to study on one hand the early mitochondrial alterations, common or specific, occurring in peripheral cells of patients with Alzheimer's disease or related dementia and, on the other hand, identify the metabolomic biomarkers that may be at the origin of mitochondrial disturbances associated with the disease. This will be the first study combining functional analyses of mitochondria and exploratory metabolomic assessments in the same cohort at early stages of the disease.

NCT Number	NCT06880406
Lead Sponsor	Centre Hospitalier Universitaire de Nice
Conditions	Alzheimer Disease
Enrollment	250 participants
Start Date	2025-07-01
Primary Completion	2028-07-01 (estimated)
Study Completion	2029-04-01 (estimated)
Updated on ClinicalTrials.gov	2026-06-18