Neuromodulatory Effects of Audio-proprio-phonatory Reinforcement Training on Subjective Tinnitus, Demonstrated by High-density Electroencephalogram (HD EEG)

Our ecological approach to neuromodulation in the field of "acouphonology" empowers tinnitus patients to act as their own source of sound stimuli through audio-proprio-phonatory reinforcement (APPR). By engaging in self-phonations, individuals uncoverthe vast potential for sound production, which can effectively mask their tinnitus or induce residual inhibition, all without relying on external sources. This clinical study aims to illustrate the positive impact of audio-proprio-phonatory reinforcement training on individuals suffering from chronic subjective tinnitus. This will be further supported and quantified through high-definition electroencephalography (HD EEG) as we explore the relationship between changes in connectivity within specific brain regions and the varying degrees of response to the therapeutic protocol.

NCT Number	NCT06880367
Lead Sponsor	Centre Hospitalier Régional d'Orléans
Conditions	Tinnitus, Subjective
Enrollment	56 participants
Start Date	2025-03-18
Primary Completion	2028-09-18 (estimated)
Study Completion	2028-09-18 (estimated)
Updated on ClinicalTrials.gov	2025-12-30