Postprandial Metabolome and Metabolic Flexibility

Metabolic flexibility is a process in which the body can switch energy substrates in different physiological states. This flexibility plays an important role in an individual's health because losing it increases the risk of obesity, metabolic syndrome, insulin resistance, and type 2 diabetes. Considering that humans spend most of their awakening hours in a postprandial (PP) state, an organism's metabolic flexibility (MF) to respond to a standardized meal's consumption would provide information on the individual's metabolic health. The PP response to glucose following an oral glucose tolerance test or consumption of a high-carbohydrate meal is well described; however, few studies assess the FM and PP metabolome using mixed meals with different macronutrients. The investigators address how metabolic flexibility and metabolome change after consuming standardized meals with different macronutrient ratios. Data collection includes clinical and diet information, indirect calorimetry, and capillary blood sampling during fasting and after consumption of standardized meals. Samples are collected weekly for one month. The data will determine the metabolic flexibility and metabolome after consuming standardized meals with different macronutrient ratios.

NCT Number	NCT06878781
Lead Sponsor	Instituto Nacional de Medicina Genomica Collaborators: Universidad Nacional Autonoma de Mexico
Conditions	Fasting, Postprandial Hyperglycemia, Lipid Metabolism Disorders, Glucose Metabolism Disorders, Insulin Sensitivity
Enrollment	300 participants
Start Date	2024-01-08
Primary Completion	2026-01-30 (estimated)
Study Completion	2026-12-18 (estimated)
Updated on ClinicalTrials.gov	2025-03-17