Clinical Trial

On-treatment Surveillance of Tumor Evolution and Response to Systemic Treatment in Bile Duct and Liver Cancer

Study acronym: BILLIONSTARS

Recruiting

Summary

The BILLIONSTARS study is a prospective, single arm observational study inviting patients diagnosed with hepatocellular carcinoma (HCC) or cholangiocarcinoma (CCC) who are to be recommended locoregional intervention by surgery, ablation or transarterial chemoembolization and/or antitumoral medical treatment. The aim is to investigate how tumor- and individual-related factors affect response to treatment. To this end, circulating tumor DNA, immune cells and various proteins will be analyzed in repeated blood samples taken before, during and after completion of systemic treatment. When applicable, analyses will also be performed on tumor tissue from resected tumors and biopsies, and in some cases also from autopsies

Protocol Amendment History 2 amendments

This ClinicalTrials.gov record has been amended 2 times since 2025-03-11; most recent amendment 2025-05-23.

Status change: Not Yet Recruiting → Recruiting 2025-05-15

Trial Details

NCT Number	NCT06877637
Lead Sponsor	Region Skane
Conditions	Hepatocellular Carcinoma (HCC), Cholangiocarcinoma
Enrollment	150 participants
Start Date	2025-05-15
Primary Completion	2026-12-31 (estimated)
Study Completion	2029-12-31 (estimated)
Updated on ClinicalTrials.gov	2026-08-03