Clinical Trial

LORLATINIB-related HYPERLIPIDEMIA in ALK+ Non-Small Cell Lung Cancer

Enrolling by Invitation
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Record status
This record was last updated March 14, 2025 (before its estimated September 2025 completion). Its status may not reflect the trial's current state.
Summary
The goal of this observational study is to learn about the long-term effects of Lorlatinib related hyperlipidemia in NSCLC patients who take Lorlatinib for at least 21 days. The main question it aims to answer is: * Whether blood lipids have been lowered down to an anticipated level within recommended range after the initial revealed Lorlatinib related hyperlipidemia? * Will it be harmful to the cardiovascular system when blood lipids were not lowered down to normal levels in these cancer patients treated with Lorlatinib, i.e. major adverse cardiac events (MACE), or instead, carotid artery intima-media thickness. Participants already taking Lorlatinib as part of their regular medical care for NSCLC will answer online survey questions.
Trial Details
NCT Number NCT06876675
Lead Sponsor Peking University Third Hospital
Conditions Non-Small Cell Lung Cancer, Hyperlipidemia
Enrollment 167 participants
Start Date 2024-10-15
Primary Completion 2025-09 (estimated)
Study Completion 2029-08 (estimated)
Updated on ClinicalTrials.gov 2025-03-14