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Study of EN-374 Gene Therapy in Participants With X-Linked Chronic Granulomatous Disease

StatusActive, Not Recruiting
PhasePhase 1/2
SponsorEnsoma
Started
View on ClinicalTrials.gov ↗

Record History

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  1. Enrollment closed, study ongoing
    • Site details revised at 9 of 9 sites
    • Eligibility criteria shortened, about 5 words
    v12
  2. Site contacts updated at 1 of 9 sitesv11
  3. Study sites: 8 to 9v10
  4. Study sites: 7 to 8v9
  5. Study sites: 5 to 7v8
Show 6 earlier versionsHide 6 earlier versions
  1. Study sites: 4 to 5v7
  2. Study sites: 3 to 4v6
  3. Study sites: 2 to 3v5
  4. Study sites: 1 to 2v4
  5. Trial status: Not Yet Recruiting to Recruiting
    • Study sites: 0 to 1
    • Start date changed from estimate of Jul 2025 to Aug 5, 2025
    v3
  6. Eligibility criteria shortened, about 11 wordsv2
  1. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
Ensoma
2 trials monitored
See 1 trial at risk
The goal of this clinical trial is to evaluate the safety and potential efficacy of the EN-374 treatment regimen and identify a dose level for further evaluation in participants with x-linked chronic granulomatous disease. The main questions it aims to answer are: * safety of the EN-374 treatment regimen * effect of the EN-374 treatment regimen on the production of functional neutrophils with NADPH oxidase activity
Trial Details
NCT Number NCT06876363
Lead Sponsor Ensoma
Conditions
(from sponsor)		 X-Linked Chronic Granulomatous Disease
Related terms Granulomatous Disease, Chronic
Enrollment 15 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov