Pronase in Improving Endoscopic Mucosal Clarity During Colonoscopy for Patients with Colitis

Pronase is a proteolytic enzyme known for its ability to clear mucus by breaking down its main component, mucin, through enzymatic hydrolysis. This property makes it useful in gastroscopy, where it is employed to improve the visibility of the mucosal surface during endoscopic examinations. Given the same mechanism, pronase may also be beneficial in enhancing mucosal clarity during colonoscopy. This multicenter, prospective, double-blind randomized controlled trial is designed to assess the effectiveness and safety of pronase in improving mucosal visibility in patients with colitis during endoscopy.

NCT Number	NCT06874673
Lead Sponsor	Changhai Hospital Collaborators: Affiliated Hospital of Jiangnan University, The Affiliated People's Hospital of Ningbo University, Shanghai 8th People's Hospital, Huashan Hospital, Shanghai Baoshan District Wusong Central Hospital, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Pudong Hospital, The People's Hospital of Leshan, Shanghai Pudong New Area Gongli Hospital, Huadong Hospital, Shanghai Songjiang District Central Hospital, Jinshan Hospital Fudan University, Dongfang Hospital Affiliated to Tongji University, Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University
Conditions	Pronase, Mucosal Clarity
Enrollment	438 participants
Start Date	2025-03-17
Primary Completion	2025-09-30 (estimated)
Study Completion	2025-11-30 (estimated)
Updated on ClinicalTrials.gov	2025-03-13