Comparison Between Vaginal Misoprostol Gel and Oral Misoprostol Solution in Induction of Labor

The goal of this clinical trial is to study the efficacy of vaginal versus oral misoprostol solution in cervical ripening for induction of labor. The main questions it aims to answer is : is Vaginal misoprostol solution as effective as oral misoprostol solution for induction of labor? Researchers will compare oral Misoprostol Solution and vaginal misoprostol solution prepared by KY gel Participants will then be randomized into two groups using a computer-generated randomization list , the first group will receive oral solution equal to 25 microgram misoprostol every 2 hours while the second group will receive 25 microgram vaginal misoprostol solution every 4 hours The cervix will be assessed and scored at each examination. They will be reviewed before the stipulated time if they were contracting. The administration of the drugs will be discontinued when a favorable cervix is diagnosed (modified Bishop score ≥6 ) or 24 hours of study drug had been given.

NCT Number	NCT06874049
Lead Sponsor	Hagar Muhammad Abdulfattah Muhammad
Conditions	Cervical Ripening and Induction of Labor
Enrollment	80 participants
Start Date	2025-02-26
Primary Completion	2025-08 (estimated)
Study Completion	2025-09 (estimated)
Updated on ClinicalTrials.gov	2025-03-13