Evaluating the Impact of a Functional and Cognitive Strategy in Patients With Long Covid-19

This study aims to evaluate the impact of a functional and cognitive rehabilitation strategy compared to evidence-based informational messages, on functional capacity, cognitive abilities, quality of life, and disease progression in adults with chronic non-communicable diseases (NCDs) and Long Covid-19. Researchers will compare a structured rehabilitation program to informational support through evidence-based messages to determine if rehabilitation leads to better functional and cognitive outcomes in patients with Long Covid-19. Participants will be randomly assigned to one of two groups: 1. Functional and cognitive rehabilitation: Attending weekly in-person sessions for 8 weeks, including supervised physical and cognitive exercises. 2. Informational support: Receiving weekly evidence-based educational messages for 8 weeks. Participants will undergo assessments at baseline, post-intervention, and six months later, including a six-minute walk test, handgrip strength measurement, and questionnaires on disability, anxiety, depression, fatigue, dyspnea, cognitive function, and quality of life.

NCT Number	NCT06871293
Lead Sponsor	Fundación Cardioinfantil Instituto de Cardiología Collaborators: Hospital Militar Central, Colombia
Conditions	Long COVID-19 Syndrome, COVID 19, Noncommunicable Disease, Hypertension, Diabetes Mellitus, Long COVID
Enrollment	374 participants
Start Date	2025-10-30
Primary Completion	2026-12-31 (estimated)
Study Completion	2027-01-01 (estimated)
Updated on ClinicalTrials.gov	2026-04-13