Impact of Sarcopenia on Dyspnea in Patients With Asthma

Dyspnea in asthma, is mainly due to airway obstruction but can be caused by several alternative diagnoses. The impact of sarcopenia on dyspnea in patients with asthma is unknown. Sarcopenic asthma had a reduced physical activity and is associated with airway obstruction compared to non-sarcopenic asthma. In patients with obstructive pulmonary disease, sarcopenia is associated with shallow breathing and diverse sensory and affective components of exertional dyspnea . The morbidity of sarcopenia is also increased by systemic inflammation and the production of inflammatory cytokines as found in inflammatory airway obstruction. The investigators will investigate the prevalence and impact of sarcopenia in asthmatics patients. This will enable to better manage sarcopenia in asthmatic patients, understand its origins and personalize treatment.

NCT Number	NCT06870890
Lead Sponsor	University Hospital, Clermont-Ferrand
Conditions	Sarcopenia, Asthma, Dyspnea, Dyspnea; Asthmatic, Cytokines, Adipokines, Myokine, Muscle Disorder
Enrollment	100 participants
Start Date	2025-03-25
Primary Completion	2025-10 (estimated)
Study Completion	2026-10 (estimated)
Updated on ClinicalTrials.gov	2025-03-11