Clinical Trial

Neuroinflammation in FTLD

Active, Not Recruiting
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Summary
The goal of this observational study is to investigate the role of neuroinflammation in frontotemporal lobar degeneration (FTLD). The main aims of this study are: 1. To elucidate the role and timing of neuroinflammation in FTLD by using a combination of clinical measures, 7T MRI, and CSF biomarkers; 2. To differentiate FTLD-TDP and FTLD-tau during life using biomarkers for neuroinflammation; 3. To identify biomarkers to predict and monitor disease progression in FTLD; Secondary aim: 1\. To explore the role of brain clearance in the disease process of FTLD. Participants will undergo 7T MRI scans, blood and CSF collection, clinical, neurological, and neuropsychological evaluation.
Protocol Amendment History 1 amendment
This ClinicalTrials.gov record has been amended once since 2025-03-10.
Status change: Recruiting → Active, Not Recruiting 2025-09-04
Trial Details
NCT Number NCT06870838
Lead Sponsor Leiden University Medical Center
Collaborators: Erasmus Medical Center
Conditions Corticobasal Syndrome(CBS), Primary Progressive Aphasia(PPA), Progressive Supranuclear Palsy(PSP), Behavioral Variant Frontotemporal Dementia (bvFTD), Frontotemporal Lobar Degeneration (FTLD)
Enrollment 110 participants
Start Date 2023-07-25
Primary Completion 2025-08-01 (estimated)
Study Completion 2026-08 (estimated)
Updated on ClinicalTrials.gov 2025-09-11