Oral Anticoagulation Versus Left Atrial Appendage Occlusion Added to Direct Oral Anticoagulation in Patients with Stroke Despite Oral

A total of 380 patients with ischemic stroke despite OAC will be included. Patients will be randomized 1:1 to the best medical treatment (control) or the combination of LAAO and DOAC or OAC. The study's primary endpoint will be the occurrence of a cardioembolic event (ischemic stroke or arterial peripheral embolism) within the first 12 months after inclusion.

NCT Number	NCT06869811
Lead Sponsor	Hospital Clinic of Barcelona Collaborators: Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau, Hospital San Carlos, Madrid, Hospital Álvaro Cunqueiro, Hospital Universitari de Bellvitge, University of Salamanca
Conditions	Left Atrial Appendage Closure
Enrollment	380 participants
Start Date	2024-07-22
Primary Completion	2027-02-22 (estimated)
Study Completion	2027-07-22 (estimated)
Updated on ClinicalTrials.gov	2025-03-11