Minimally Invasive Pelvic Exenteration in Vaginal or Cervical Cancer Recurrence

The aim of this clinical trial is to assess the oncologic safety of minimally invasive pelvic exenteration in patients with recurrence or persistence of cervical or vaginal cancer with pelvic location, suitable for pelvic exenteration according to the ESGO guidelines (European Society of Gynecological Oncology). The primary aim is to assess the 3-year disease-free survival (DFS). The secondary aim is to assess the 3-year overall survival (OS), the intraoperative and post-operative complication rate, and the patient's quality of life.

NCT Number	NCT06867445
Lead Sponsor	Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Conditions	Cervical Cancers, Vaginal Cancers
Enrollment	64 participants
Start Date	2025-07-07
Primary Completion	2028-03-01 (estimated)
Study Completion	2031-03-01 (estimated)
Updated on ClinicalTrials.gov	2025-07-17