Clinical Trial

Comparison of Two Intravenous Drug Combinations for Ambulatory Oral & Maxillofacial Surgery

Completed Phase 1
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Summary
The purpose of this pilot study was to compare two commonly employed intravenous drug combinations; I) nitrous oxide, midazolam, fentanyl, and ketamine and II) the same combination with substitution of propofol for ketamine, for use during wisdom teeth extraction. Measures of recovery, amnesia testing 20 minutes after induction and after completion of recovery tests, patient satisfaction, and surgeon satisfaction will be evaluated. The data from this pilot study will be used to obtain preliminary estimates of effect sizes and to select primary and secondary endpoints for the design of a larger scale and more definitive trial of the two anesthetic approaches.
Protocol Amendment History 1 amendment
This ClinicalTrials.gov record has been amended once since 2025-03-05.
Trial Details
NCT Number NCT06867068
Lead Sponsor Albert Einstein College of Medicine
Conditions Anesthesia, Tooth Extraction
Enrollment 73 participants
Start Date 2016-10-04
Primary Completion 2024-06-10 (estimated)
Study Completion 2024-06-10 (estimated)
Updated on ClinicalTrials.gov 2026-03-27