Exploratory Clinical Study on the Efficacy and Safety of Lactobacillus Johnsonii in the Treatment of Patients with Premature Ovarian Insufficiency

The goal of this clinical trial is to explore the effectiveness and safety of Lactobacillus johnsonii in improving ovarian function and perimenopausal symptoms in patients with premature ovarian insufficiency (POI). The main questions it aims to answer are: ① To explore the effectiveness and safety of Lactobacillus johnsonii in improving ovarian function and perimenopausal symptoms in patients with POI; ② To explore the potential mechanism of action of Lactobacillus johnsonii in improving ovarian function and perimenopausal symptoms in patients with POI. Participants who meet all the inclusion criteria will be enrolled in the study and randomly assigned in a 1:1 ratio to either the Lactobacillus johnsonii group or the placebo group.

NCT Number	NCT06866990
Lead Sponsor	Second Affiliated Hospital, School of Medicine, Zhejiang University
Conditions	Premature Ovarian Insufficiency
Enrollment	60 participants
Start Date	2025-03
Primary Completion	2026-11 (estimated)
Study Completion	2027-08 (estimated)
Updated on ClinicalTrials.gov	2025-03-10