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Pain Perception During Intra-Articular Knee Joint Injection: What is the Effect of Needle Gauge and the Use of Ethyl Chloride?

StatusNot Yet Recruiting
PhasePhase 4
Started
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Record History

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  1. Notable Start date: Aug 2026 to Dec 2026
    • Interventions: +/- Ethyl Chloride Topical Aerosol Anesthetic (Procedure), 22 gauge needle (Procedure), 25 gauge needle (Procedure) to +/- Ethyl Chloride Topical Aerosol Anesthetic (Procedure), 22 gauge needle (Procedure), 25 gauge needle (Procedure)
    • Eligibility criteria expanded, about 14 words
    • Secondary endpoints: details revised at 2 of 2 entries
  2. Notable Primary and study completion pushed from May 2026 to Dec 2026
    • Start date: May 2026 to Aug 2026
    v4
  3. Notable Start date: May 2025 to May 2026v3
  4. Notable Primary and study completion dates: May 2025 to May 2026
    • Start date: Mar 2025 to May 2025
    • Collaborators shortened, about 6 words
    v2
  5. Minor Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
This study aims to investigate factors that affect the subjective experience of pain during and after intra-articular knee joint injection of steroids by comparing needle gauge size (22 G vs 25 G needles), as well as the presence or absence of topical ethyl chloride spray. Additionally, this study will investigate the effects of other various factors on patients' pain associated with the injection. Lastly, this study aims to determine the effect of patients' subjective pain from the injection on long-term clinical outcomes. Specific aims are as follows: Aim 1): Determine the effect of needle gauge size on patient reported pain associated with an ultrasound-guided intra-articular knee injection. Aim 2): Determine the effect of ethyl chloride spray on patient reported pain associated with an ultrasound-guided intra-articular knee injection. Aim 3): Determine the effect of sex, age, BMI, thigh size, severity of OA, and fear of needles on patient pain associated with an ultrasound-guided intra-articular knee injection. Aim 4) Determine the effect of patient pain from the procedure on longer term clinical outcomes after an ultrasound-guided intra-articular knee steroid injection. Researchers will obtain data at various time points, including pre-procedural data, immediately after the procedure, 24-48 hours after, and 6 weeks post-procedure. Participants will: Consent to receiving an intra-articular knee joint injection with steroids if indicated. Score their "procedural" pain immediately following the procedure, score their post-procedural "soreness" 24-48 hours after via telephone call, and score their overall knee pain about 6 weeks after the procedure via telephone call.
Trial Details
NCT Number NCT06865170
Lead Sponsor University of California, Davis
Conditions
(from sponsor)
Osteoarthritis (OA) of the Knee, Fear of Needles
Related terms Iatrophobia, Osteoarthritis
Enrollment 88 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov