The Effect of Arterial Carbon Dioxide Levels on Cerebral Blood Flow and Cerebral Autoregulation in the Steep Trendelenburg Position During Robot-assisted Prostatectomy, and Its Effect on Postoperative Cognition

Patients scheduled for robot-assisted prostatectomy will be randomized to either high or low concentrations of carbon dioxide in the blood. This will be managed by applying different ventilation strategies during anesthesia.The levels will be distinctly different. The investigators will assess whether different concentrations of carbon dioxide in blood results in different brain blood flow levels and different intracranial pressure during laparascopic surgery in the head-down tilted position. The investigators also will assess if different carbon dioxide level will manifest in different cognitive abilities in the two study groups, measured on day 1 post-surgery.

NCT Number	NCT06865027
Lead Sponsor	University Hospital, Akershus Collaborators: University of Oslo
Conditions	Intracranial Pressure, Circulation System, Cerebral Perfusion Pressure, Cognitive Function
Enrollment	46 participants
Start Date	2025-01-24
Primary Completion	2026-05-04 (estimated)
Study Completion	2026-05-28 (estimated)
Updated on ClinicalTrials.gov	2026-06-02