Liver Transplantation for Unresectable Intrahepatic Colangiocarcinoma After Sustained Response to Neoadjuvant Treatments

This is single-arm, observational, academic, investigator-driven study investigating the efficacy of liver transplantation after successful and sustained downstaging/tumor control of liver-limited unresectable intrahepatic cholangiocarcinoma. The downstaging protocol includes chemotherapy +/- immunotherapy and transarterial radioembolization (TARE) with Yttrium-90 in various combinations.

NCT Number	NCT06862934
Lead Sponsor	Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
Conditions	Intrahepatic Cholangiocarcinoma (Icc)
Enrollment	14 participants
Start Date	2025-03-20
Primary Completion	2027-12-31 (estimated)
Study Completion	2027-12-31 (estimated)
Updated on ClinicalTrials.gov	2025-03-06