PRospective phenotypIng and Multi-omic Endotyping of Progressive Pulmonary Fibrosis

This is a prospective, observational cohort study. Participants with non-idiopatic pulmonary fibrosis, interstitial lung disease (ILD) will be followed for 24 months to systematically collect clinical, imaging, and biospecimen data. The primary objective is to optimize progressive pulmonary fibrosis (PPF) classification and establish PPF incidence for key ILD subtypes. Additional exploratory objectives are to 1) Prospectively validate a novel PPF classifier and assess performance durability over time, and 2) Determine whether multi-dimensional PPF prediction outperforms component approaches.

NCT Number	NCT06855329
Lead Sponsor	University of Massachusetts, Worcester Collaborators: University of Michigan, University of Virginia, Johannes Gutenberg University Mainz, Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Conditions	Progressive Pulmonary Fibrosis, Interstitial Lung Disease
Enrollment	500 participants
Start Date	2025-05-01
Primary Completion	2029-12 (estimated)
Study Completion	2029-12 (estimated)
Updated on ClinicalTrials.gov	2025-09-22