Prokinetics and Body Surface Gastric Mapping in Dyspeptic Patients: Baseline and Treatment Effects

Functional dyspepsia and gastroparesis are common stomach disorders with symptoms like early satiety, nausea, and abdominal pain, and are often evaluated with gastric emptying tests, although the correlation with symptoms is weak. Prokinetic agents (e.g., metoclopramide, erythromycin) and symptom modulators (e.g., nortriptyline, mirtazapine) are commonly used, but selecting the right medication can be difficult, as it's often based on symptoms rather than the underlying gastric issues. Body Surface Gastric Mapping (BSGM) using the Gastric Alimetry device is a novel, non-invasive tool to assess gastric myoelectrical activity and symptoms. This study aims to perform two BSGM recordings-one before and one after medical therapy-to understand how medications affect gastric function and identify baseline BSGM factors that could predict responses to treatment, potentially guiding tailored therapies based on individual gastric dysfunction.

NCT Number	NCT06854120
Lead Sponsor	University of Auckland, New Zealand Collaborators: University of Western Sydney, Temple University, North Shore Hospital, New Zealand
Conditions	Gastroparesis, Functional Dyspepsia
Enrollment	125 participants
Start Date	2025-02-26
Primary Completion	2028-02-26 (estimated)
Study Completion	2028-08-26 (estimated)
Updated on ClinicalTrials.gov	2026-06-11