Gene Discovery in CHB Patients to Identify Unknown Pathways That Lead to B and NK Cell Deregulation

Natural Killer (NK) and B cell immune responses occur during the early stages of infection and are essential to eradicate it. Yet, chronic hepatitis B (CHB) infection occurs because the antiviral immune response is insufficient. In both NK and B cell studies we will explore the genetic alterations that occur during the varied chronic stages of the disease. We believe that our findings will allow us to understand the molecular signature of NK and B cells in the context of HBV infection.

NCT Number	NCT06853886
Lead Sponsor	University Hospital, Limoges Collaborators: National Agency for Research on AIDS and Viral Hepatitis (ANRS)
Conditions	Chronic Hepatitis B Virus
Enrollment	140 participants
Start Date	2025-08-12
Primary Completion	2028-10-01 (estimated)
Study Completion	2028-10-01 (estimated)
Updated on ClinicalTrials.gov	2026-05-20