Evaluation of Alterations in the Gut Microbiota in Pediatric Bronchial Asthma

Asthma constitutes a major chronic noncommunicable disease, globally it affects about 300 million people and the incidence has been steadily increasing in recent decades; it affects about 10% of children and is the leading chronic disease in childhood. The microbiota constitutes the collection of all microorganisms-bacteria, viruses, fungi, protozoa-that live in symbiosis with our bodies. Disruption of the microbiota during this critical period of development can cause asthma, allergies, and other immunological disorders. Therefore, it can be an important environmental factor that determines the transition of health to disease. The aim of the intended study is to evaluate and analyze the presence of possible alterations in the gut microbiota in a cohort of pediatric asthmatic subjects by collecting fecal samples.

NCT Number	NCT06842836
Lead Sponsor	Azienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo di Alessandria
Conditions	Asthma Bronchiale
Enrollment	20 participants
Start Date	2024-05-06
Primary Completion	2024-12-31 (estimated)
Study Completion	2025-12-31 (estimated)
Updated on ClinicalTrials.gov	2025-09-15