During Chest Surgery, One Lung is Isolated From Ventilation to Improve Visibility, With Carbon Dioxide Introduced Between the Lung and Chest Wall (Capnothorax): the Study Seeks to Optimize Ventilation Through Esophageal Pressure Measurement, Reducing Respiratory Complications.

The objective of this single-center observational study is to improve the safety and effectiveness of chest surgery through the use of a new ventilation technique. During the operation, to allow the surgeon to work more precisely, only one lung will receive air from the respirator. To improve visibility during surgery, a small amount of carbon dioxide is introduced into the space between the lung and the chest wall, a procedure called capnothorax. The aim of the research is to find the best way to set the patient's ventilation during the operation, ensuring adequate oxygenation and minimizing the risks to the lung. To do this, we will use a method of measuring the pressure inside the esophagus, which will allow us to better understand the status of the lungs and adjust ventilation accordingly. Esophageal pressure is an indirect measure of the pressure within the lung. By measuring this pressure, we can get important information about the status of the lungs and their ability to expand and contract. By measuring esophageal pressure, researchers will be able to set ventilation more precisely, optimizing the amount of air that is supplied to the lungs and the pressure inside the lungs themselves. This could help prevent lung damage and improve the patient's breathing during and after surgery, reducing respiratory complications and improving patients' quality of life. General data collected at the beginning of the study and before the surgical intervention: * date of birth, gender, weight, and height, * information and scores regarding the fitness for general anesthesia techniques, * anesthesia risk assessment made by the American Society of Anesthesiologists (ASA), * data related to respiratory mechanics. Data collected during the surgical intervention: * data related to respiratory mechanics measured at the ventilator, * data recorded by the optivent monitor to which the esophageal probe is connected, * hemodynamic data collected through a semi-invasive arterial blood pressure monitoring system, * arterial blood gas analysis, * pulmonary ultrasound findings.

NCT Number	NCT06837636
Lead Sponsor	Cardarelli Hospital
Conditions	Capnothorax, One Lung Ventilation, Thoracic Surgery, Esophageal Pressure Measurement
Enrollment	36 participants
Start Date	2025-02-20
Primary Completion	2026-02-20 (estimated)
Study Completion	2026-03 (estimated)
Updated on ClinicalTrials.gov	2025-02-25