Clinical Trial

PEEP vs. ZEEP in Out-of-Hospital-Cardiac-Arrest

Study acronym: PerAVent
Recruiting
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Record status
This record was last updated August 6, 2025 (before its estimated June 30, 2026 completion). Its status may not reflect the trial's current state.
Summary
Out-of-hospital cardiac arrest (OHCA) remains a major cause of mortality, with low survival probabilities to hospital discharge. Despite the frequent use of airway management and mechanical ventilation during resuscitation, there is limited evidence regarding the optimal ventilation strategy to improve oxygen delivery and patient outcomes. The present study aims to investigate the effects of positive-end-expiratory-pressure (PEEP) set at 5 mbar compared to zero-end-expiratory-pressure (ZEEP) on the return of spontaneous-circulation (ROSC) in adult patients with OHCA.
Protocol Amendment History 2 amendments
This ClinicalTrials.gov record has been amended 2 times since 2025-02-15; most recent amendment 2025-08-05.
Status change: Not Yet Recruiting → Recruiting 2025-08-05
Trial Details
NCT Number NCT06836830
Lead Sponsor Muehlenkreiskliniken, MKK
Conditions Ventilation Therapy, PEEP, Occult, CPR, Cardiac Arrest (CA)
Enrollment 600 participants
Start Date 2025-06-01
Primary Completion 2026-06-30 (estimated)
Study Completion 2026-10-31 (estimated)
Updated on ClinicalTrials.gov 2025-08-06