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PEEP vs. ZEEP in Out-of-Hospital-Cardiac-Arrest

Study acronym: PerAVent
StatusRecruiting
PhaseNot applicable
Started
View on ClinicalTrials.gov ↗
Record status
This record was last updated August 6, 2025 (before its estimated June 30, 2026 completion). Its status may not reflect the trial's current state.

Record History

  1. Trial status: Not Yet Recruiting to Recruitingv3 Show 4 more changesShow less
    • Start date changed from estimate of Mar 1, 2025 to Jun 1, 2025
    • Study sites: 0 to 3
    • Primary completion date: Mar 31, 2026 to Jun 30, 2026
    • Study completion date: Mar 31, 2026 to Oct 31, 2026
  2. Secondary endpoints: details revised at 2 of 6 entriesv2
  3. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
Out-of-hospital cardiac arrest (OHCA) remains a major cause of mortality, with low survival probabilities to hospital discharge. Despite the frequent use of airway management and mechanical ventilation during resuscitation, there is limited evidence regarding the optimal ventilation strategy to improve oxygen delivery and patient outcomes. The present study aims to investigate the effects of positive-end-expiratory-pressure (PEEP) set at 5 mbar compared to zero-end-expiratory-pressure (ZEEP) on the return of spontaneous-circulation (ROSC) in adult patients with OHCA.
Trial Details
NCT Number NCT06836830
Lead Sponsor Muehlenkreiskliniken, MKK
Conditions
(from sponsor)		 Ventilation Therapy, PEEP, Occult, CPR, Cardiac Arrest (CA)
Related terms Heart Arrest, Positive-Pressure Respiration, Intrinsic, Respiratory Aspiration
Enrollment 600 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov