Clinical Trial

Ritual Synbiotic+, a Dietary Supplement Designed to Impact Gastrointestinal Health, Mood, and Behavior in Women

Study acronym: SYN
Active, Not Recruiting
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Record status
This record was last updated June 24, 2026 (before its estimated August 1, 2026 completion). Its status may not reflect the trial's current state.
Summary
The aim of this study is to determine how regular consumption of Synbiotic+, a dietary supplement that contains prebiotics, probiotics, and postbiotics, impacts functional gastrointestinal health, markers of intestinal inflammation and immune health, and influences mood and behavior. The primary outcome will be to assess gastrointestinal health using bowel movement tracking, self-report and objective assessments of gastrointestinal symptom severity, stool levels of short chain fatty acids, changes in the gut microbiota, including recovery of LGG and BB-12, and functional measures of the microbiome. Secondary outcomes will include stool and blood markers of gut barrier function and intestinal inflammation, immune health, and self-assessments of stress, anxiety, sleep, and quality of life.
Protocol Amendment History 3 amendments
This ClinicalTrials.gov record has been amended 3 times since 2025-02-14; most recent amendment 2026-06-22.
Status change: Recruiting → Active, Not Recruiting 2026-06-22
Status change: Not Yet Recruiting → Recruiting 2025-05-15
Trial Details
NCT Number NCT06834984
Lead Sponsor Colorado State University
Collaborators: Ritual
Conditions Gastrointestinal Disease Symptoms
Enrollment 60 participants
Start Date 2025-05-01
Primary Completion 2026-08-01 (estimated)
Study Completion 2026-08-01 (estimated)
Updated on ClinicalTrials.gov 2026-06-24