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High Intensity Interval Training in the Treatment of Familial Hypercholesterolemia (UPPA-FH)

Study acronym: UPPA-FH
StatusRecruiting
PhaseNot applicable
Started
View on ClinicalTrials.gov ↗
Trial flagged as At Risk
Primary completion moved at least 8 months later Jun 2026 → Feb 28, 2027
See other at-risk trials from Fundación Pública Andaluza para la Investigación Biomédica Andalucía Oriental

Record History

See every version on ClinicalTrials.gov ↗

  1. Primary completion pushed from Jun 2026 to Feb 28, 2027 Show 7 more changesShow less
    • Recruitment opened
    • Study completion pushed from Jul 31, 2026 to Jul 31, 2027
    • Start date changed from estimate of Feb 15, 2025 to Feb 20, 2025
    • Eligibility criteria expanded, about 8 words
    • Secondary endpoints: 63 to 18
    • Study description revised
    • Site details revised
  2. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
This study has one main objective: a) To assess the impact of two different supervised exercise interventions on cardiorespiratory fitness and markers of subclinical atherosclerosis in patients with Familiar Hipercolesterolemia (FH), and to unravel the underlying mechanisms behind these effects. The starting hypothesis of the UPPA-FH project anticipates that both exercise interventions will produce a large increase in cardiorespiratory fitness and will improve significant markers of atherosclerosis in patients with FH, with high-intensity interval training program (HIIT) being more efficient than the moderate-intensity continuous training (MICT) modality. The main effects will be mediated by a significant change in the metabolomic signature of the participants. In addition, higher physical activity will be associated with more favorable markers of atherosclerosis progression, as shown through blood and image technique
Trial Details
NCT Number NCT06833944
Lead Sponsor Fundación Pública Andaluza para la Investigación Biomédica Andalucía Oriental
Conditions
(from sponsor)		 Familiar Hypercholesterolemia
Related terms Cardiovascular Diseases, Motor Activity
Enrollment 75 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov