High Intensity Interval Training in the Treatment of Familial Hypercholesterolemia (UPPA-FH)

This study has one main objective: a) To assess the impact of two different supervised exercise interventions on cardiorespiratory fitness and markers of subclinical atherosclerosis in patients with Familiar Hipercolesterolemia (FH), and to unravel the underlying mechanisms behind these effects. The starting hypothesis of the UPPA-FH project anticipates that both exercise interventions will produce a large increase in cardiorespiratory fitness and will improve significant markers of atherosclerosis in patients with FH, with high-intensity interval training program (HIIT) being more efficient than the moderate-intensity continuous training (MICT) modality. The main effects will be mediated by a significant change in the metabolomic signature of the participants. In addition, higher physical activity will be associated with more favorable markers of atherosclerosis progression, as shown through blood and image technique

NCT Number	NCT06833944
Lead Sponsor	Fundación Pública Andaluza para la Investigación Biomédica Andalucía Oriental
Conditions	Familiar Hypercholesterolemia
Enrollment	75 participants
Start Date	2025-02-15
Primary Completion	2026-06 (estimated)
Study Completion	2026-07-31 (estimated)
Updated on ClinicalTrials.gov	2025-02-19