Ramadan Fasting Outcomes in Patients With Secondary Adrenal Insufficiency Before and After the Treatment of Hypotension.

Intermittent fasting in patients with adrenal insufficiency is associated with an increased risk of complications, such as dehydration. A recent study showed that nearly half the patients had hypotension before the fasting month and half had signs of dehydration during fasting. So, we are planning to carry out this prospective interventional study in patients with SAI and hypotension to evaluate the effect of treating hypotension with fludrocortisone on the risk of complications during fasting. Patients with secondary adrenal insufficiency and hypotension and who are willing to fast during Ramadan 2025 will be included. Before Ramadan, they will be treated with fludrocortisone at a dose of 50micg/day. The occurrence of complications and the number of fasted days during Ramadan 2025 will be reported and compared with those of Ramadan 2023.

NCT Number	NCT06832566
Lead Sponsor	Hopital La Rabta
Conditions	Secondary Adrenal Insufficiency, Hypotension
Enrollment	20 participants
Start Date	2025-02-15
Primary Completion	2025-04-15 (estimated)
Study Completion	2025-04-15 (estimated)
Updated on ClinicalTrials.gov	2025-02-18