Acute Concussion Management in Emergency Medicine with 7T MRI: a Feasibility Study

The goal of this observational study is to learn about the brain imaging changes associated with concussion using a very detailed (7T) MRI scanner. To do this, the investigators will study 7T MRI brain imaging in patients aged 18-40 who present to the Emergency Department within 96 hours of a head injury. Patients will be eligible if they have had a normal CT brain as part of their usual care. The investigators will compare brain imaging from patients who have completely recovered from an episode of concussion to patients who still have significant symptoms at approximately 28 days after a head injury. The study attempts to answer the following questions: 1. Do patients with ongoing symptoms after concussion show greater 7T MRI brain imaging evidence of changes to the blood vessels at approximately 28 days after their injury in comparison to patients who have recovered fully? 2. Do patients with ongoing symptoms after concussion show greater 7T MRI brain imaging evidence of changes in brain signaling pathways at approximately 28 days after their injury, in comparison to patients who have recovered fully?

NCT Number	NCT06830616
Lead Sponsor	NHS Greater Glasgow and Clyde
Conditions	Traumatic Brain Injury (TBI); Concussion, Initial Encounter
Enrollment	20 participants
Start Date	2025-02
Primary Completion	2025-08 (estimated)
Study Completion	2025-11 (estimated)
Updated on ClinicalTrials.gov	2025-02-20