Domperidone on the Composition of Preterm Breastmilk Using a Human Milk Mid-infrared Spectroscopy Analyzer

Maintaining milk production in lactating mothers who have delivered prematurely can be a challenge. In these cases, domperidone has been the most commonly used pharmacologic galactagogue. There are several studies on the effect of this drug on the volume of milk produced, but data on its effect on the macronutrient and energy content is scarce. The mid-infrared spectroscopy is a convenient validated method to assess human milk macronutrient and energy content because it requires little training for its operation and a small volume of milk. This study aims to determine the effect of domperidone on the macronutrient and energy content of milk from women who have delivered prematurely, and to compare the results obtained with those reported using reference methods for this analysis.

NCT Number	NCT06830226
Lead Sponsor	Centro Hospitalar de Lisboa Central
Conditions	Insufficient Breast Milk Syndrome, Premature Birth
Enrollment	81 participants
Start Date	2025-01-08
Primary Completion	2025-07-30 (estimated)
Study Completion	2025-08-30 (estimated)
Updated on ClinicalTrials.gov	2025-03-18