Clinical Trial

Establishing a Controlled Human Infection Model of Pertactin-deficient Bordetella Pertussis

Recruiting Phase 1
View on ClinicalTrials.gov →
Summary
The overall goal of this study is to establish a PRN-deficient pertussis Controlled Human Infection Model (CHIM) that represents currently circulating isolates, in the context of a North American exposure (vaccination and infection) pedigree.
Protocol Amendment History 3 amendments
This ClinicalTrials.gov record has been amended 3 times since 2025-02-10; most recent amendment 2025-11-27.
Status change: Not Yet Recruiting → Recruiting 2025-11-27
Trial Details
NCT Number NCT06827470
Lead Sponsor Dalhousie University
Collaborators: Centers for Disease Control and Prevention
Conditions Pertussis (Whooping Cough)
Enrollment 60 participants
Start Date 2025-11-24
Primary Completion 2026-12-31 (estimated)
Study Completion 2027-04-30 (estimated)
Updated on ClinicalTrials.gov 2025-12-04