7T Anatomo-functional Characterization of Structures in the Action Observation Network

The goal of this study is to explore the anatomical-functional characteristics of the AON circuit (with particular interest for subcortical areas and the cerebellum), and the cortico-subcortical connectivity of the nodes of the AON circuit, using an ultra-high field (7T), high spatial resolution Magnetic Resonance Imaging protocol. The main questions it aims to answer are: * Can we demonstrate the involvement of subcortical areas and cerebellum in the AON circuit in each single-subject? * Can we obtain similar results in a small group of patients with Cerebral Palsy (CP), in order to demonstrate the feasibility of this approach for the study of the mechanisms of AON reorganization, after early brain damage? * Are different patterns of functional activation correlated to different clinical characteristics of CP patients? Participants will perform a 7 Tesla MRI scan, with a functional and anatomical dedicated protocol and will have a comprehensive clinical assessment before the MRI exam.

NCT Number	NCT06826287
Lead Sponsor	IRCCS Fondazione Stella Maris Collaborators: University of Parma, Fondazione IMAGO7
Conditions	Brain Function, Cerebral Palsy
Enrollment	40 participants
Start Date	2024-12-02
Primary Completion	2025-08-09 (estimated)
Study Completion	2025-08-09 (estimated)
Updated on ClinicalTrials.gov	2025-02-13