The Implementation and Impact of an Allergy De-Labeling Program in the Emergency Department

Beta-lactams are the most common antibiotics prescribed to children, including penicillin and amoxicillin. They are usually more effective and have fewer side effects than other ty antibiotics. Some children can have reactions to these antibiotics that can be mistaken as an allergy, especially rashes that develop days to weeks later. In such cases, when children take the antibiotic again, they have no problem tolerating it; this is called "delabeling an allergy" with an "oral challenge". Based on our experience with a similar program among inpatients, we are implementing and evaluating an allergy delabeling program for children in the SickKids ED, with the hope and intent to delabel most children of their "allergies" using an oral challenge.

NCT Number	NCT06823154
Lead Sponsor	The Hospital for Sick Children
Conditions	Allergy Amoxicillin, Beta-lactam Allergy Labels
Enrollment	500 participants
Start Date	2023-11-27
Primary Completion	2026-02-17 (estimated)
Study Completion	2026-12-31 (estimated)
Updated on ClinicalTrials.gov	2026-05-07